Dr. Santosh Kumar Behera

Ph.D. Berhampur University, 2013.

Dr. Santosh Kumar Behera, Ph. D

Scientist

Tele: -+91 79 66745555

E-mail : santosh.behera@niperahm.ac.in

Research Interest

  • I received my Ph.D. in Bioinformatics from Berhampur University. I took a challenging research problem on "Computational Biology of Cyanobacteria, Invertebrate and Vertebrate Mucin using Bioinformatics tools and SDS-PAGE Analysis." In my Ph.D. findings, I have predicted and validated the two- and three-dimensional structures for the mucin proteins (glycoproteins) using various computational tools and techniques that are found to be novel. The finding of my study contributed significantly to the knowledge with special reference to the mucin proteins from various organisms and their structure, functionality and evolutionary relationships. The study was carried out to find the interactions between mucins, human diseases and its associated organs to explore their potential use as diagnostic, prognostic markers and as therapeutic targets in various diseases.
  • To explore the gut microbiota in newly diagnosed diabetic patients, I have performed NGS analysis. Presently, I am involved in various aspects of health informatics such as an In-silico analysis of various inhibitors using combinatorial tools for development and identification of potential inhibitors as anti-cancer and anti-viral, therapeutics. Taking the advent computational chemistry in drug discovery process has emphasized the development of new technologies for design, synthesis, screening and decoding of combinatorial library of drugs. One of my investigations was carried out to report the better inhibition efficacy among Ganetespib, Fluorouracil and its combinatorial drug treatment (Ganetespib+Fluorouracil) against Hsp90 molecular chaperone through in-silico approach. Collaborative research is been carried out to solve the alarming issues of COVID-19, and vector borne diseases, through explorative exchange of scientific thoughts virtual screening and, network pharmacology. Most of my investigations are based of in-silico protein structure prediction and validation followed by structure-based or ligand-based drug design, virtual screening and molecular dynamics simulations.
  • Data mining and Structural Biology
  • Computational chemistry, Molecular Modeling, Docking and molecular dynamics simulation
  • Virtual screening, Pharmacophore modeling, Drug designing, network pharmacology and System Biology
  • Gene Regulatory Network (GRN) analysis

Experience

    • October 2020 - Present:
      Scientist, NIPER-Ahmedabad (INDIA)
    • June 2018 - October 2020:
      Programme Officer, ICMR-Regional Medical Research Centre, Bhubaneswar, Odisha (India)
    • April 2014 - March 2018:
      Project Scientist II, ICMR-Regional Medical Research Centre, Bhubaneswar, Odisha (India)
    • January 2008 - April 2014:
      Research Associate (RA), Bioinformatics Infrastructure Facility Centre sponsored by DBT, Govt. of India at Berhampur University, Berhampur Odisha (India)

Honors/Awards/Grants/Consultancies

Awards

  • Award of Excellence (My Best Mentee) from SRM Medical College Hospital & Research Centre, Tirchy, Tamilnadu in the 6th National Workshop on Research Methodology, organized on 20th to 23rd March, 2019

Publications

  • Santosh Kumar Behera, Nazmina Vhora, Darshan Contractor, Amit Shard, Dinesh Kumar, Kiran Kalia. (2021). Computational drug repurposing study elucidating simultaneous inhibition of entry and replication of novel corona virus by Grazoprevir, scientific reports. 11, 7307. doi.org/10.1038/s41598-021-86712-2
  • Santosh Kumar Behera, Rudradip Das, Tanay Dalvi, Arnab Chowdhury, Bhaskar Dewangan, Kiran Kalia, Amit Shard, * Bichismita Sahu * (2020) Design and in-silico screening of Peptide Nucleic Acid (PNA) inspired novel pronucleotide scaffolds targeting COVID-19. Current Computer-Aided Drug Design. DOI: 10.2174/1573409916666200923143935
  • Begum Dariya, Santosh Kumar Behera, Gowru Srivani, Sheik Aliya, Afroz Alam & Ganji Purnachandra Nagaraju (2020). Resveratrol binds and activates RKIP protein in colorectal cancer. Amino Acids ; 52:1299–1306.
  • Santosh Kumar Behera, Namita Mahapatra, Chandra Sekhar Tripathy & Sanghamitra Pati*(2020). Drug repurposing for identification of potential inhibitors against SARS-CoV-2 spike receptor-binding domain (RBD): an in silico approach. Indian Journal of Medical Research. doi: 10.4103/ijmr.IJMR_1132_20.
  • Pujarini Dash, Jyotirmayee Turuk*, Santosh Ku. Behera, Subrata Ku. Palo1, Sunil K. Raghav, Arup Ghosh, Jyotsnamayee Sabat, Sonalika Rath, Subhra Subhadra, Debadutta Bhattacharya, Srikant Kanungo, Jayasingh Kshatri, Bijaya kumar Mishra, Saroj Dash, Namita Mahapatra, Ajay Parida, Sanghamitra Pati(2020).Sequence analysis of Indian SARS-CoV-2 isolates shows a stronger interaction of mutated receptor binding domain with ACE2 receptor. International Journal of Infectious Diseases (Accepted).
  • Gowru Srivani, Santosh Kumar Behera, Begum Dariya, Gayathri Chalikonda, Afroz Alam & Ganji Purnachandra Nagaraju. (2020) HIF-1α and RKIP: a computational approach for pancreatic cancer therapy. Molecular and Cellular Biochemistry. https://doi.org/10.1007/s11010-020-03788-6.
  • Gowru Srivani, Santosh Kumar Behera, Begum Dariya, Sheik Aliya, Afroz Alam, Ganji Purnachandra Nagaraju, Resveratrol binds and inhibits transcription factor HIF-1α in pancreatic cancer. Experimental Cell Research. 2020 May 30; 112126. doi: 10.1016/j.yexcr.2020.112126.
  • Begum Dariya, Santosh Kumar Behera, Gowru Srivani, Batoul Farran, Afroz Alam, Ganji Purnachandra Nagaraju. Computational analysis of nuclear factor-jB and resveratrol in colorectal cancer. J Biomol Struct Dyn. 2020; 1-9. https://doi.org/10.1080/07391102.2020.1757511.
  • Ganji Purnachandra Nagaraju , Gowru Srivani, Begum Dariya, Gayathri Chalikonda, Batoul Farrana,Santosh Kumar Behera, Afroz Alam, Mohammad Amjad Kamal, Nanoparticles guided drug delivery and imaging in gastric cancer. Seminars in Cancer Biology. Available online 16 January 2020.In Press. https://doi.org/10.1016/j.semcancer.2020.01.006.
  • Vidya Mukund*, Santosh Kumar Behara, Afroz Alam & Ganji PurnachandraNagaraju, (2019).Molecular docking analysis of nuclear factor-κB and genistein interaction in the context of breast cancer. Bioinformation 15(1): 11-17.
  • Krishna Kumar Das, Sudeepa Rout, Santosh Kumar Behera* and Yagyan Prasad Nath Sharma, (2019). Computational Biology And Gene Interpretation Of Psoriatic Arthritis Through In silico Analysis. World Journal of Pharmaceutical Research, 8(2): 2019:1232-12-52.
  • Krishna Kumar Das, Himansu Sekhar Behera and Santosh Kumar Behera*, (2019). In silico Analysis And Molecular Docking To Predict The Impact Of Genes Associated With Rheumatoid Arthritis. World Journal of Pharmaceutical Research, 8(2): 2019:1082-1099.
  • Praharaj AB, Dehury B, Mahapatra N, Kar S.K and Behera SK,(2018). Molecular Dynamics insights into the structure, function and substrate binding mechanism of mucin desulfating sulphatase of gut microbe Bacteroides fragilies. Journalof Cellular Biochemistry,Wiley. 119(4):3618-3631.
  • Praharaj AB, Behera SK, Dehury B and Mahapatra N, (2017). New Insights Into The Gut Microbiome Research To Understand The Microbial Diversity Of Indian And Western Populations With Type II Diabetes Mellitus: A Short Review. World Journal of Pharmaceutical Research. 6(16): 1423-1436.
  • Surabhi Kavitha, Santosh Kumar Behera, Sheik Aliya and Adepelly Uma, (2017). A Bioinformatics Approach for Identification of Micro-organism Showing Highest Homology for Lipase B Gene. World Journal of Pharmaceutical Sciences. 5(10): 8-19.

Book/Book Chapter/Peer Review Abstract

Peer Review Abstract

  • S.B. Padhi, P.K. Swain, S.K.Behera and G. Behera (2010). Industrial Utilization of Algal Fatty Acids. Book: Algal Biotechnology New Vistas. Daya Publishing House, Delhi - 110 035, www.dayabooks.com. ISBN 978-81-7035-647-9.
  • Santosh Kumar Behera, Ardhendu Bhusan Praharaj, Gayathri Chalikonda, Gowru Srivani, and Namita Mahapatra (2020). Gut Microbiota as Signatures in Non-communicable Diseases and Mucosal Immunity. Book: Theranostics Approaches to Gastric and Colon Cancer. Springer Nature Singapore Pte Ltd. 152 Beach Road, #21-01/04 Gateway East, Singapore 189721, Singapore. ISSN 2662-2688, ISSN 2662-2696 (electronic), ISBN 978-981-15-2016-7, ISBN 978-981-15-2017-4 (eBook).
Presentations:
International:
Projects:
Completed
Ph.D:
Completed:
Ongoing 1
MS Dissertation:
Completed: 07
Ongoing:
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