Giriraj Sahu, Ph.D.
Research Interest : Dr. Giriraj’s research focuses on studying the cellular mechanisms that regulate the excitability of principal neurons of the brain, targeting specific ion channel proteins and their interacting protein
partners. In a healthy brain, neuronal excitability is finetuned by both excitatory and inhibitory signal mechanisms but, this process gets compromised in neurological disorders such as aging, epilepsy, and in neurodegenerative disease states. Dr. Giriraj’s
group at NIPER-A identifying the systems that coordinate this excitatory/inhibitory balance and the molecular details that alter this balance in disease states. For this Dr. Giriraj’s group applies advanced techniques like patch clamping, live-cell FRET, analytical
biochemistry, and super-resolution microscopy (STORM, SRRF, TIRF) tools using in-vitro cultured neuronal preparations, brain slices, and conducting in-vivo rodent animal studies. Through this, Dr. Giriraj aims to contribute to the development of novel drug
targets and candidates for the treatment of neurological disordersRead More