Siddheshwar Chauthe, Ph. D

PDF Department of Oncology, Georgetown University Medical Center, Washington D.C. USA, 2015.

Ph.D. Department of Natural Products, National Institute of Pharmaceutical Education and Research, Mohali, 2012

Dr. Siddheshwar Kisan Chauthe

Assistant Professor

Tele : +91 79 66745555, 8550919900

E-mail : Siddheshwar.chauthe@niperahm.ac.in,siddheshwarchauthe@gmail.com

Research Interest

  • Bioassay-guided isolation, structure elucidation and synthetic modification of bioactive compounds from medicinal plants.
  • Development of analytical methods for standardization of polyherbal formulations using hyphenated techniques.
  • To establish Q-markers for the quality standards of traditional Ayurvedic /herbal medicines.

Experience

  • March 2020 -Present:
    Assistant Professor, NIPER- Ahmedabad, Palaj, Gandhinagar.
  • October 2019-March 2020:
    Senior Research Investigator (Team Lead LCMS and HPLC Sections), Biocon-BMS R&D Center (BBRC), Syngene International Ltd, Bangalore.
  • April 2016-September 2019:
    Research Investigator (Team Lead LCMS and HPLC Sections), Biocon-BMS R&D Center (BBRC), Syngene International Ltd, Bangalore.
  • March 2014- Nov 2015:
    Research Specialist-II (Post Doc), Metabolomics Center, Georgetown University Medical Center, USA.
  • June 2012 - March 2014:
    Assistant Manager, Pharmaceutical R&D, GlaxoSmithKline, Nashik, India.
  • March 2005 - Aug 2006:
    Research Associate, R & D, Piramal Life Sciences, Limited, Mumbai.
  • May 2004 - Dec 2005:
    R&D Officer, R & D, Sami Labs Limited, Bangalore.

Honours/Awards/Grants/Consultancies

Honours/Awards

  • BBRC Bravo Award for developing LCMS based preparative HPLC method development approach (2016).
  • NIH Common Fund Metabolomics Initiative: $1000 travel award to attend the 2nd Annual UAB Workshop on Metabolomics, June 2nd – 5th, 2014.
  • Three GlaxosmithKline Bravo awards for successfully driving various R & D projects (2012-13).
  • Won $8800 Innocentive award for solving the Innocentive challenge entitled "Process Mass Intensities.” Sponsored by Merck Pharmaceutical Inc, 2010.
  • Won $1000 Innocentive award for solving the Innocentive challenge entitled "Novel Sources for Extraction of Xanthophyll Carotenoids”(2010).
  • Senior Research Fellowship, Council of scientific and industrial research (CSIR), Ministry of Science and Technology, India (2010-12).
  • Senior Research Fellowship, Department of biotechnology (DBT), Ministry of Science and Technology, India (2008-2010).
  • Junior Research Fellowship, Department of biotechnology (DBT), Ministry of Science and Technology, India (2006-2008).
  • Master program Fellowship, Graduate aptitude test in engineering (GATE) conducted by IIT Madras (2002).

Publications

  • Asokan, K.; Shaikh, K.M.; Tele, S.S ; Chauthe, S.K, Ansar, S.; Vetrichelvan, M.; Nimje, R.; Gupta, A.; Gupta, A.K.; Sarabu, R.; Wu, D.-R.; Mathur, A.; Bajpai, L., Applications of 2, 2, 2 trifluoroethanol as a versatile co-solvent in supercritical fluid chromatography for purification of unstable boronate esters, enhancing throughput, reducing epimerization and for additive free purifications, J. Chromato. A, 2018, 1531, 22-130.
  • Tiwari, R.; Ahire, D.; Kumar, H.; Sinha, S.; Chauthe, S.K, Subramanian, M.; Iyer, R.; Sarabu, R.; Bajpai, L., Use of hybrid capillary tube setup on 400MHz NMR for quantitation of crucial low quantity metabolites using aSICCO signal, Drug Metab Dispos. 2017, 45, 1215-1224.
  • Laiakis, E.C.; Pannkuk, E.L.; Chauthe, S.K, Wang, Y.-W.; Lian, M. Mak, T.D.; Barker, C.A.; Astarita, G.; Fornace, A., A serum small molecule biosignature of radiation exposure from total body irradiated patients, J. Proteome Res., 2017, 16, 3805–3815.
  • Goudarzi, M.; Chauthe, S.K, Strawn, S.J.; Weber, W.M.; Brenner, D.J.; Fornace, A.J., Quantitative analysis of urinary citrulline and calcitroid acid in mice after external beam gamma-irradiation or exposure to internal emitters, Int. J. Mol. Sci. 2016, 17, 782.
  • Chauthe, S.K, Mahajan, S.; Rachamalla, M.; Tikoo, K.; Singh, I. P. Synthesis and evaluation of linear furanocoumarins as potential anti-breast and anti-prostate cancer agents, Med. Chem. Res. 2015, 24, 2476-84.
  • Chauthe, S.K, Bharate, S. B.; Periyasamy, G.; Khanna, A.; Bhutani, K. K.; Mishra, P. D.; Singh, I. P. One pot synthesis and anticancer activity of dimeric phlorolglucinols, Bioorg. Med. Chem. Lett. 2012, 22, 2251-2256.
  • Chauthe, S.K,; Sharma, R. J.; Gupta, R. C.; Singh, I. P. qNMR: An applicable method for standardization of Indian medicinal plants extracts and their herbal formulations, Phytochem. Anal. 2012, 23, 689-96.
  • Chauthe, S.K, Bharate, S. B.; Sabde, S.; Mitra, D.; Bhutani, K. K.; Singh, I. P. Biomimetic synthesis and anti-HIV activity of dimeric phloroglucinols. Bioorg. Med. Chem. 2010, 18, 2029-2036.
  • Sabde, S.; Bodiwala, H. S.; Karmase, A.; Deshpande, P. J.; Kaur, A.; Ahmed, N.; Chauthe, S.K,Brahmbhatt, K. G.; Phadke, R. U.; Mitra D.; Bhutani, K. K. and Singh, I. P. Anti HIV activity of Indian medicinal plants, J. Nat. Med. 2011, 65, 662-669
  • Bharate, S. B.; Khan, S. I.; Yunus, N. A. M.; Chauthe, S.K, Jacob, M. R.; Tekwani, B. L.; Khan, A.; Singh, I. P. Antiprotozoal and antimicrobial activities of O-alkylated and formylatedacylphloroglucinols. Bioorg. Med. Chem. 2007, 15, 87–96.
  • Bharate S. B.; Chauthe, S.K, Bhutani K. K.; Singh I. P. An efficient two-step synthesis of jensenone. Synthesis of analogues and evaluation as antioxidants. Aust. J. Chem. 2005, 58, 7, 551-555.
  • Singh, I. P.; Chauthe, S.K, Small molecule HIV entry inhibitors-Part I: Chemokine receptor antagonists - 2004-2010, Expert Opin. Ther. Pat. 2011, 21, 227–269.
  • Singh, I. P.; Chauthe, S.K, Small molecule HIV entry inhibitors-Part II: Attachment and fusion inhibitors - 2004-2010, Expert Opin. Ther. Pat. 2011, 21, 399–416.

Book/Book Chapter/Patents/Peer Review Abstract

Book Chapters

  • Cheema, A. K.; Chauthe, S. K. Drug discovery and evaluation: Pharmacological assays, Quantitative metabolomics, edited by Franz J. Hock. 2015, pp 1-10, DOI: 10.1007/978-3-642-27728-3_115-1.

Patents

  • Title: Tumor Necrosis Factor - Alpha Inhibitors, Inventors: Sarala Balachandran; Ram Vishwakarma; Kaki Venkatrao;Yadav Vitthal;Siddheshwar Chauthe; Somesh Sharma; Parikh Sapna; KharasFiruza, PCT PATENT application No-WO2008142623 ; Filed on 16th May 2008.
  • Title: Novel dimeric phloroglucinol compounds as anti-HIV and microbicidal agents, Inventors: Inder Pal Singh,Kamlesh Kumar Bhutani, DebashishMitra,Siddheshwar Chauthe, SandipBharate and SudeepSabde. Indian patent granted application; Patent no: 289013.
Presentations:
National : 07
International: 03
Projects:
Completed 00
Ongoing 00
PhD:
Completed 00
Ongoing 00
MS Dissertation:
Completed 00
Ongoing 00
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