Ph.D. NIPER SAS Nagar (Mohali), India, 2010

Dr. Ravi Shah

Assistant Professor

Tele : 079-66745555

E-mail : ravi.shah@niperahm.ac.in ,ravi.niper@gmail.com

Research Interest

    Development of analytical strategies for drug development and discovery with specific focus on:

  • Characterization of complex APIs and biosimilars
  • Characterization of complex formulations and sameness strategy development for regulatory submission
  • In-vitro release and its correlation with formulation strategies
  • Bioanalytical, biomarker analysis and metabolomics
  • LC-MS and NMR based characterization of impurities, drug-drug/ drug-excipient interaction products and degradation products
  • Pre-formulation assessment including polymorph characterization, salt screening, drug- excipient compatibility studies, rheological assessment, particle properties

Experience

  • February 2019 – Present:
    Assistant Professor, Department of Pharmaceutical Analysis, NIPER Ahmedabad, Gujarat, India.
  • August 2015 – February 2019
    Principal Scientist, Associate Director- AR&D,Integrated Product Development Organization, Dr. Reddy’s Laboratory, Bangalore.
  • April 2015 - July 2015:
    Senior Principal Investigator, AR&D Biocon-Bristol Myers Squibb R&D Center, Bangalore
  • May 2013 – March 2015:
    Principal Investigator, AR&D Biocon-Bristol Myers Squibb R&D Center, Bangalore.
  • April 2011 – April 2013:
    Research Investigator, AR&D Biocon-Bristol Myers Squibb R&D Center, Bangalore.
  • Octomber 2010 – March 2011:
    Associate Scientific Manager, AR&D Biocon-Bristol Myers Squibb R&D Center, Bangalore
  • July 2007 – September 2010:
    PhD Scholar, Department of Pharmaceutical Analysis, NIPER-SAS Nagar, Mohali

Honours/Awards/Grants/Consultancies

Awards

  • PoC of the Year 2018, Dr. Reddy’s Laboratories.
  • Galaxy BMS Award, Biocon-Bristol Myers Squibb R&D Center.
  • Team Triumph Award, Biocon-Bristol Myers Squibb R&D Center.
  • Individual Triumph Award, Biocon-Bristol Myers Squibb R&D Center.
  • Golden R&D Star Award, Biocon-Bristol Myers Squibb R&D Center.
  • Team Triumph Award, Biocon-Bristol Myers Squibb R&D Center.
  • Golden R&D Star Award, Biocon-Bristol Myers Squibb R&D Center.
  • AAPS Travel Award, American Association of Pharmaceutical Scientists.
  • Best Poster Presentation Award, Indian Pharmaceutical Congress.
  • Innocentive award with Cash prize of US $15000, Innocentive Inc.
  • Second prize in oral presentation, Indian Society for Mass Spectrometry.
  • DST Travel Award for presenting research work at British Pharmaceutical Conference.
  • Best Out-Going Student of the batch: B.Pharm 2001-2005 SGRS CoP, Pune University.
  • Merit Scholarship Award, Sir Ratan Tata Trust.

Publications

  • R.P. Shah, A. Garg, S.P. Putlur, S. Wagh, V. Kumar, V. Rao, S. Singh, S. Mandlekar, S. Desikan, Practical and economical implementation of online H/D exchange in LC-MS., Anal. Chem. 85; 10904–10912. doi:10.1021/ac402339s.
  • R.P. Shah, V. Kumar, S. Singh, Liquid chromatography/mass spectrometric studies on atorvastatin and its stress degradation products., Rapid Commun. Mass Spectrom. 22; 613–22. doi:10.1002/rcm.3403.
  • R.P. Shah, A. Sahu, S. Singh, Identification and characterization of degradation products of irbesartan using LC-MS/TOF, MS(n), on-line H/D exchange and LC-NMR., J. Pharm. Biomed. Anal. 51; 1037–46. doi:10.1016/j.jpba.2009.11.008.
  • R.P. Shah, S. Singh, Identification and characterization of a photolytic degradation product of telmisartan using LC-MS/TOF, LC-MSn, LC-NMR and on-line H/D exchange mass studies., J. Pharm. Biomed. Anal. 53; 755–61. doi:10.1016/j.jpba.2010.05.005.
  • R.P. Shah, A. Sahu, S. Singh, LC-MS/TOF, LC-MSn, on-line H/D exchange and LC-NMR studies on rosuvastatin degradation and in silico determination of toxicity of its degradation products: a comprehensive approach during drug development., Anal. Bioanal. Chem. 405; 3215–31. doi:10.1007/s00216-013-6760-1.
  • S. Singh, T. Handa, M. Narayanam, A. Sahu, M. Junwal, R.P. Shah, A critical review on the use of modern sophisticated hyphenated tools in the characterization of impurities and degradation products, J. Pharm. Biomed. Anal. 69; 148–173. doi:10.1016/j.jpba.2012.03.044.
  • V. Kumar, R.P. Shah, S. Singh, LC and LC-MS methods for the investigation of polypills for the treatment of cardiovascular diseases. Part 1. Separation of active components and classification of their interaction/degradation products., J. Pharm. Biomed. Anal. 47; 508–15. doi:10.1016/j.jpba.2008.01.041.
  • S. Mehta, R.P. Shah, S. Singh, Strategy for identification and characterization of small quantities of drug degradation products using LC and LC-MS: Application to valsartan, amodel drug, Drug Test. Anal. 2; 82–90. doi:10.1002/dta.116.
  • M. Narayanam, T. Handa, P. Sharma, S. Jhajra, P.K. Muthe, P.K. Dappili, R.P. Shah, S. Singh, Critical practical aspects in the application of liquid chromatography-mass spectrometric studies for the characterization of impurities and degradation products, J. Pharm. Biomed. Anal. 87; 191–217. doi:10.1016/j.jpba.2013.04.027.
  • S. Singh, B. Prasad, A.A. Savaliya, R.P. Shah, V.M. Gohil, A. Kaur, Strategies for characterizing sildenafil, vardenafil, tadalafil and their analogues in herbal dietary supplements, and detecting counterfeit products containing these drugs, TrAC - Trends Anal. Chem. 28; 13–28. doi:10.1016/j.trac.2008.09.004.

Books/Book Chapters/Patents/Peer Review -Abstracts

Patents

  • Title: Substentially Pure Canagliflozin.
  • Country: PCT/World patent.
  • Filing year: 2017.
  • Patent application No.: WO 2017/093949
Presentations:
National : 20
International: 03
Projects:
Completed 01
Ongoing 01
PhD:
Completed 00
Ongoing 01
MS Dissertation:
Completed 00
Ongoing 06
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