Dr. Giriraj Sahu, Ph. D

RA University of Calgary, Alberta, Canada, 2020.

PDF University of Calgary, Alberta, Canada, 2019.

PDF Leibniz Institute for Neurobiology, Magdeburg, Germany, 2014.

Ph.D. Indian Institute of Technology Madras, Chennai, India, 2013.

Dr. Giriraj Sahu, Ph. D

Assistant Professor

Tele : +91-8260853235

E-mail : girirajsahu@niperahm.ac.in, girirajsahu@gmail.com

Research Interest

Dr. Giriraj’s research focuses on studying the cellular mechanisms that regulate the excitability of principal neurons of the brain, targeting specific ion channel proteins and their interacting protein partners. In a healthy brain, neuronal excitability is finetuned by both excitatory and inhibitory signal mechanisms but, this process gets compromised in neurological disorders such as aging, epilepsy, and in neurodegenerative disease states. Dr. Giriraj’s group at NIPER-A identifying the systems that coordinate this excitatory/inhibitory balance and the molecular details that alter this balance in disease states. For this Dr. Giriraj’s group applies advanced techniques like patch clamping, live-cell FRET, analytical biochemistry, and super-resolution microscopy (STORM, SRRF, TIRF) tools using in-vitro cultured neuronal preparations, brain slices, and conducting in-vivo rodent animal studies. Through this, Dr. Giriraj aims to contribute to the development of novel drug targets and candidates for the treatment of neurological disorders

Experience

  • July 2020 - Present:
    Assistant Professor, Dept. of Biotechnology, NIPER-Ahmedabad, Palaj, Gandhinagar
  • April 2019 - June 2020:
    Research Associate, Hotchkiss Brain Institute, University of Calgary, Alberta, Canada
  • December 2014 - March 2019:
    Postdoctoral Fellow, Cumming School of Medicine, University of Calgary, Alberta, Canada.
  • September 2013 - November 2014:
    Postdoctoral Fellow, Leibniz Institute for Neurobiology, Magdeburg, Germany
  • July 2009 - July 2013:
    Senior Research Fellow, Indian Institute of Technology Madras, Chennai, India
  • July 2007 - July 2009:
    Junior Research Fellow, Indian Institute of Technology Madras, Chennai, India

Honours/Awards/Grants/Consultancies

Honours

  • Invited Judge, Undergraduate Poster Presentation (2017), University of Calgary, Canada.
  • Invited Talk at Canadian Light Microscopy Course (2015), University of Calgary, Canada.

Awards

  • Daniel T.O' Connor Memorial Early Career Investigator Award (2020), at International Symposium on Chromaffin Cell Biology (ISCCB-2020).
  • Brain Star Award (2019), from the Canadian Association for Neuroscience (CAN) and the Canadian Institutes of Health’s Institute of Neurosciences, Mental Health and Addiction (CIHR-INMHA).
  • AIHS - Postdoctoral Fellowship (2016 - 2019), from the Alberta Innovates-Health Solutions (AIHS), Alberta, Canada.
  • Eyes High - Postdoctoral Fellowship (2014 - 2016), from the Vice president’s office, University of Calgary, Alberta, Canada.
  • DAAD postdoctoral fellowship (2013 - 2014), from the German Academic Exchange Service, Germany.
  • Postdoctoral Fellowship (2013), from Marie Curie Initial Training Network, Magdeburg, Germany.
  • DST-SRF fellowship (2012 - 2013) from the Department of Science and Technology, Govt. of India.
  • Received Travel Grant (2011), for attending international gap junction conference 2011 from the Indian Institute of Technology Madras, Chennai, India.
  • DBT-SRF fellowship (2009 - 2012), from the Ministry of Science and Technology, Govt. of India.
  • DBT-JRF fellowship (2007 - 2009), from the Ministry of Science and Technology, Govt. of India.
  • Cleared Graduate Aptitude Test Exam, 2007 (GATE-2007), Conducted by IITs and IISc. Govt. of India.
  • Cleared National Eligibility Test, 2007 (NET-2007), Conducted by the University Grants Commission, Govt. of India.

Grants

  • International Society for Neurochemistry (ISN) Return Home Grant (2020-2021); Title: Mechanism of slow afterhyperpolarization modulation in temporal lobe epilepsy. Role: Principle Investigator.

Publications

  • Zhan X, Asmara H, Cheng N, Sahu G, Sanchez E, Zhang FX, Zamponi GW, Rho JM, Turner RW. FMRP(1-297)-tat restores ion channel and synaptic function in a model of Fragile X syndrome. Nature Communications. 2020; 11(1):2755. (IF: 12.2)
  • Sahu G, Wazen RM, Colarusso P, Chen WR, Zamponi GW, Turner RW. Junctophilin proteins tether a Cav1.3-RyR2-KCa3.1 tripartite complex to regulate neuronal excitability. Cell Reports. 2019; 28:2427-2442.e6. (IF: 8.2)
  • Higham J, Sahu G, Wazen RM, Colarusso P, Gregorie A, Harvey BSJ, Goudswaard L, Varley G, Sheppard DN, Turner RW, Marrion NV. Preferred formation of heteromeric channels between co-expressed SK1 and IKCa channel subunits provides a unique pharmacological profile of Ca2+-activated potassium channels. Molecular Pharmacology. 2019; 96(1):115-126. (IF: 4.0)
  • Sahu G, Asmara H, Zhang FX, Zamponi GW, Turner RW. Activity-dependent facilitation of CaV1.3 calcium channels promotes KCa3.1 activation in hippocampal neurons. Journal of Neuroscience. 2017; 37(46):11255-11270. (IF: 6.1)
  • Asmara H, Ileana M, Rizwan AP, Sahu G, Simms BA, Zhang FX, Engbers JDT, Stys PK, Zamponi GW, Turner RW. A T-type channel-calmodulin complex triggers alpha-CaMKII activation. Molecular Brain. 2017; 10(1):37. (IF: 4.0)
  • Grochowska KM, Yuanxiang P, Bär J, Raman R, Brugal G, Sahu G, Schweizer M, Bikbaev A, Schilling S, Demuth HU, Kreutz MR. Posttranslational modification impact on the mechanism by which amyloid-β induces synaptic dysfunction. EMBO Reports. 2017; 18(6):962-981. (IF: 8.7)
  • Turner RW, Asmara H, Engbers JDT, Miclat J, Rizwan AP, Sahu G, Zamponi GW. Assessing the role of IKCa channels in generating the sAHP of CA1 hippocampal pyramidal cells. Channels. 2016; 10(4):313-9. (IF: 2.5)
  • Tewari D, Mukhopadhyay M, Nekkanti MS, Vallabhaneni S, Sahu G, Jetti SK, Preethidan DS, Bera AK. Cytoprotective effect of Centella asiatica is mediated through the modulation of mitochondrial voltage-dependent anion channel (VDAC) and scavenging of free radicals. Journal of Functional Foods. 2016; 21: 301-311. (IF: 3.5)
  • Kesavan R, Chandel S, Upadhyay S, Bendre R, Ganugula R, Potunuru UR, Giri H, Sahu G, Kumar PU, Reddy GB, Joksic G, Bera AK, Dixit M. Gentiana lutea exerts anti-atherosclerotic effects by preventing endothelial inflammation and smooth muscle cell migration. Nutrition Metabolism and Cardiovascular Diseases. 2016; 26: 293-301. (IF: 3.3)
  • Priya MK, Sahu G, Soto-Pantoja DR, Goldy N, Sundaresan AM, Jadhav V, Barathkumar TR, Saran U, Jaffar Ali BM, Roberts DD, Bera AK, Chatterjee S. Tipping off endothelial tubes: nitric oxide drives tip cells. Angiogenesis. 2015; 18: 175-189. (IF: 5.8)
  • Sahu G, Sukumaran S, Bera AK. Pannexins form gap junctions with electrophysiological and pharmacological properties distinct from connexins. Nature Scientific Reports. 2014; 4: 4955. (IF: 4.3)
  • Sahu G, Bera AK. Contribution of intracellular calcium and pH in ischemic uncoupling of cardiac gap junction channels formed of connexins 43, 40, and 45: a critical function of C-terminal domain. PLoS One. 2013; 8: e60506. (IF: 2.75)
  • Sahu BS*, Mohan J*, Sahu G*, Singh PK, Sonawane PJ, Sasi BK, Allu PK, Maji SK, Bera AK, Senapati S, Mahapatra NR. Molecular interactions of the physiological anti-hypertensive peptide catestatin with the neuronal nicotinic acetylcholine receptor. Journal of Cell Science. 2012; 125: 2323-2337. * Equal Contributions. (IF: 4.5)
  • Sahu BS, Obbineni JM, Sahu G, Allu PK, Subramanian L, Sonawane PJ, Singh PK, Sasi BK, Senapati S, Maji SK, Bera AK, Gomathi BS, Mullasari AS, Mahapatra NR. Functional genetic variants of the catecholamine-release-inhibitory peptide catestatin in an Indian population: allele-specific effects on metabolic traits. Journal of Biological Chemistry. 2012; 287: 43840-43852. (IF: 4.5)
  • Swain SM, Parameswaran S, Sahu G, Verma RS, Bera AK. Proton-gated ion channels in mouse bone marrow stromal cells. Stem Cell Research. 2012; 9: 59-68. (IF: 3.9)

Book/Book Chapter/Patents/Peer Review Abstract

Book Chapter

  • Sahu BS, Subramanian L, Allu PKR, Sahu G, Obbineni JM, Singh PK, Gomathi BS, Maji SK, Bera AK, Senapati S, Mullasari AS, Mahapatra NR. Identification and functional characterization of genetic variants of the catecholamine release inhibitory peptide Catestatin in an Indian population. In Catecholamine Research in the 21st Century: Abstracts and Graphical Abstracts, 10th International Catecholamine Symposium, 2012 (pp. 198-199). Elsevier Inc.
Presentations:
National : 01
International: 12
Projects:
Completed 00
Ongoing 01
PhD:
Completed 00
Ongoing 00
MS Dissertation:
Completed 00
Ongoing 03
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