Dr. Dinesh Kumar

PDF North Dakota State University, ND, USA, 2017

Ph.D. NIPER SAS NAGAR (Mohali), 2013

Dr. Dinesh Kumar

Assistant Professor

Tele : +91-8709447063

E-mail : dineshk@niperahm.ac.in,dineshk@niperahm.res.in

Research Interest

Development of new strategies and concepts in synthetic organic chemistry to address challenging problems in biomedical research, particularly anti-cancer drug discovery.

  • Development of new reaction methodologies
  • Discovery of anti-cancer drug candidates
  • Multi-step synthesis of pharmaceuticals and bioactive natural products
  • Green chemistry

Experience

    • Sept. 2017 - Present:
      Assistant Professor, NIPER-Ahmedabad (INDIA)
    • Nov. 2013 – Sept. 2017 :
      Post-doctoral Fellow, Department of Chemistry & Biochemistry,North Dakota State University (NDSU), Fargo, USA.
    • April 2011 - Nov. 2013:
      CSIR-Research Associate (CSIR-RA), Department of Medicinal Chemistry, NIPER SAS Nagar (Mohali), India
    • April 2009 - March 2013:
      CSIR-Senior Research Fellow (CSIR-SRF), Department of Medicinal Chemistry, NIPER SAS Nagar (Mohali), India

Honours/Awards/Grants/Consultancies

Awards

  • Best Poster award at 2nd KU-NDSU Joint Symposium on Biotechnology, Nanomaterials and Polymers, Fukushima, Japan, November 2016.
  • 1st Prize of 2013 Eli Lilly and Company Asia Outstanding Thesis Awards.
  • Research Associateship (2011) by Human Resource Development Group, Council of Scientific & Industrial Research (CSIR-HRDG), Government of India.
  • Best Poster award at 14th International Conference (ISCBC-2010) on Chemical Biology for Discovery: Perspectives and Challenges, January 2010, CDRI, Lucknow, India.
  • Senior Research Fellowship (2009) by Human Resource Development Group, Council of Scientific & Industrial Research (CSIR-HRDG), Government of India.
  • Graduate Aptitude Test in Engineering (GATE–2005 category: Pharmaceutical Sciences) with 98.64 percentile

Publications (Research Article or Review Article Max 10)

  • Dinesh Parshuram Satpute, Gargi N. Vaidya, Shyam Kumar Lokhande, Sangita Dattatray Shinde, Shivkanya Bhujbal, Deep Rohan Chatterjee, Pooja Rana, Ashwini, Mithilesh Nagpure and Dinesh Kumar. (2021). Organic Reactions in Aqueous Media Catalyzed by Nickel, Green Chemistry. doi.org/10.1039/D1GC01983J
  • Santosh Kumar Behera, Nazmina Vhora, Darshan Contractor, Amit Shard, Dinesh Kumar, Kiran Kalia. (2021). Computational drug repurposing study elucidating simultaneous inhibition of entry and replication of novel corona virus by Grazoprevir, scientific reports. 11, 7307. doi.org/10.1038/s41598-021-86712-2
  • Gargi N. Vaidya,Sneha Fiske,Hansa Verma,Shyam Kumar Lokhande and Dinesh Kumar. (2019) A Micellar Catalysis Strategy Applied to Pd-Catalyzed C-H Arylations of Indoles in Water, Green Chemistry. 10.1039/C8GC03413C (I.F. 8.586)
  • Gargi Nikhil Vaidya,Arif Khan,Hansa Verma,Sanjeev Kumar,andDinesh Kumar. (2019) Structure Ligation Relationship of Amino Acids for the Amination Cross-Coupling Reactions, Journal of Organic Chemistry. DOI: 10.1021/acs.joc.8b03214
  • Sandeep R.Vemula, Dinesh Kumar, Gregory R.Cook. (2018) Bismuth-catalyzed synthesis of 2-substituted quinazolinones, Tetrahedron Letters. 59(42), 3801-3805. https://doi.org/10.1016/j.tetlet.2018.09.014
  • Dinesh Kumar, Sandeep Reddy Vemula, Narayanaganesh Balasubramanian, and Gregory R. Cook, "Indium-mediated stereoselective allylation,” Acc. Chem. Res., 2016, 49, 2169–2178; IF 20.00.
  • Dinesh Kumar, Sandeep Reddy Vemula, and Gregory R. Cook, "Merging C–H Bond Functionalization with Amide Alcoholysis: En Route to 2-Aminopyridines,” ACS Catal., 2016, 6, 3531-353; IF 10.6.
  • Dinesh Kumar, Sandeep R. Vemula, and Gregory R. Cook, "Recent advances in catalytic synthesis of α-ketoamides,” ACS Catal., 2016, 6, 4920-4945; IF 10.6.
  • Sandeep Reddy Vemula, Dinesh Kumar, and Gregory R. Cook, "Palladium catalyzed allylic amidation with N-heterocycles via sp3 C-H oxidation,” ACS Catal., 2016, 6, 5295-5301; IF 10.6.
  • Dinesh Kumar, Sandeep Reddy Vemula, and Gregory R. Cook, "Highly chemo- and regioselective allylic substitution with tautomerizable heteroarenes,” Green Chem., 2015, 17, 4300-4306; IF 9.12.
  • Dinesh Kumar, Mukesh Sonawane, Brahmam Pujala, Varun K. Jain, Srikant Bhagat, and Asit K. Chakraborti, "Supported protic acid-catalyzed synthesis of 2,3-disubstituted thiazolidin-4- one: enhancement of the catalytic potential of protic acid by adsorbtion on solid support,” Green Chem., 2013, 15, 2872-2884; IF 9.12.
  • Dinesh Kumar, N. Kommi, Alpesh R. Patel, and Asit K. Chakraborti, "Catalytic procedures for multicomponent synthesis of imidazoles: Selectivity control during the competitive formation of tri- and tetra-substituted imidazoles,” Green Chem., 2012, 14, 2038-2049; IF 9.12.
  • Damodara N. Kommi, Dinesh Kumar, and Asit K. Chakraborti, "All water chemistry for a concise total synthesis of the anti-anginal drug (RS), (R), and (S)-ranolazine,” Green Chem., 2013, 15, 756–767; IF 9.12.
  • Damodara N. Kommi, Pradeep S. Jadhavar, Dinesh Kumar,and Asit K.Chakraborti, "All water” one-pot diverse synthesis of 1,2-disubstituted benzimidazoles: hydrogen bond driven ‘synergistic electrophile-nucleophile dual activation’ by water,” Green Chem., 2013, 15, 798– 810; IF 9.12.
  • Damodara N. Kommi, Dinesh kumar, Rohit Bansal, Rajesh Chebolu, and Asit K. Chakraborti,"All-water chemistry of tandem N-alkylation–reduction–condensation for synthesis of Narylmethyl-2-substituted benzimidazoles,” Green Chem., 2012, 14, 3329-3335; IF 9.12.; (Highlighted in RSC Blog by Mary Badcock, Development Editor, Green Chemistry).
Complete list

Books/Book Chapters/Patents/Peer Review -Abstracts

Book Chapters

  • Pradeep S. Jadhavar, Dinesh Kumar, Priyank Purohit, Bhavin V. Pipaliya, Asim Kumar, Srikant Bhagat, and Asit K. Chakraborti, Chapter Title: "Sustainable approaches towards the synthesis of quinoxalines,” Book Title: Green Chemistry: Synthesis of Bioactive Heterocycles, DOI: 10.1007/978-81-322-1850-0, Online ISBN 978-81-322-1850-0, Publisher- Springer India

Patents

  • Asit K. Chakraborti, Dinesh Kumar, Mukesh Sonawane, and Brahmam Pujala "Processes for synthesis of 2,3-disubstituted-4-thiazolidinone,” Indian Patent Appl. No. 3148/DEL/2011, Date of filing: 08/11/2011, PCT International filing date: 04/11/2011, Date of Publication: 10/05/2013.
  • Asit K. Chakraborti, Dinesh Kumar and Tushar Satav "An improved acid catalyzed one-pot synthesis of 2-styryl quinoline,” Indian Patent Appl. No. 2673/DEL/2011, Date of filing: 15/09/2011, PCT International filing date: 15/09/2011, Date of Publication: 15/03/2013.
  • Asit K. Chakraborti, Dinesh Kumar and Himanshu Sharma "An improved process for one- pot synthesis of 2-styryl-4-(3H)-quinazolinones,” Indian Patent Appl. No. 2443/DEL/2011, Date of filing: 26/08/2011, PCT International filing date: 26/08/2011, Date of Publication: 31/08/2016.
  • Asit K. Chakraborti, Dinesh Kumar Sachin Bindal, and Damodar N. Kommi "An improved process for the synthesis of alkyl ester of carboxylic acid,” Indian Patent Appl. No 2176/DEL/2011, Date of filing: 02/08/2011, PCT International filing date: 02/08/2011, Date of Publication: 11/10/2013.
  • Asit K. Chakraborti,Dinesh Kumar Kapileshwar Seth, and Damodar N. Kommi "A green procedure for synthesis of functionalized compounds,” Indian Patent. Appl. No. 2023/DEL/2011, Date of filing: 18/07/2011, PCT International filing date: 18/07/2011, Date of Publication: 25/01/2013.
  • Asit K. Chakraborti, Alpesh R. Patel, and Dinesh Kumar "An improved catalytic process for esterification of carboxylic acids,” Indian patent. Appl. No. 1046/DEL/2009, Date of filing: 21/05/2009, PCT International filing date: 21/05/2009, Date of Publication: 25/11/2010.
  • Asit K. Chakraborti, Alpesh R. Patel, and Dinesh Kumar "An improved process for esterification using organic carbonates,” Indian Patent. Appl. No. 554/DEL/2009, Date of filing: 23/03/2009, PCT International filing date: 23/03/2009, Date of Publication: 15/10/2010.
  • Asit K. Chakraborti, Dinesh Kumar, Santosh Rudraawar, Sachin Bindal, Himanshu Sharma, and Pradeep Chopra "Improved processes for synthesis of functionalized pyridines,” Indian Patent. Appl. No. 3245/DEL/2012, Date of filing: 18/10/2012, Date of Publication:15/08/2014.
  • Asit K. Chakraborti, Damodar N. Kommi, and Dinesh Kumar"Improved proceses for the synthesis of Lubeluzole,” Indian Patent Appl. No. 1962/DEL/2012, Date of filing: 26/06/2012, Date of Publication: 27/12/2013.

Peer Review Abstract

  • Dinesh Kumar, Sandeep Reddy Vemula, and Gregory R. Cook, "Ruthenium catalyzed site selective olefinic C-H bond functionalization for chemo- and regioselective annulation reaction,” 252nd ACS National Meeting & Exposition, Philadelphia, PA, August 21-25, 2016.
  • Dinesh Kumar, Sandeep Reddy Vemula, and Gregory R. Cook, "Regio and chemoselective allylation of Heterocycles,” 248th ACS National Meeting & Exposition, San Francisco, CA, United States, August 10-14,2014.
  • Sandeep Reddy Vemula, Dinesh Kumar, and Gregory R. Cook, "Investigation and exploration of transition metal catalysis for site selective C-H bond functionalizations,” 251st ACS National Meeting & Exposition, San Diego, CA, USA, March 13-17, 2016.
  • Sandeep Reddy Vemula, Dinesh Kumar, Narayanaganesh Balasubramanian, and Gregory R. Cook, "Main group metal-mediated enantioselective allylation of carbonyl compounds using substoichiometric amounts of metal,” 248th ACS National Meeting & Exposition, San Francisco, CA, USA, August 10-14, 2014.
  • Gregory R. Cook, Sandeep Reddy Vemula, Dinesh Kumar,and Narayanaganesh Balasubramanian, "New paradigm in enantioselective In-mediated allylation,” 248th ACS National Meeting & Exposition, San Francisco, CA, USA, August 10-14, 2014.

Presentations:
National: 00
International: 05
Projects:
Completed: -
Ongoing: 02
PhD:
Completed -
Ongoing: 01
MS Dissertation:
Completed -
Ongoing: 02
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