Bichismita Sahu, Ph. D

PDF Carnegie Mellon University, Pittsburgh, USA.

Ph.D. Indian Institute of Technology Bombay (IIT Bombay).

Bichismita Sahu, Ph. D

Assistant Professor

Tele : +91 8424022096

E-mail :bichismita@niperahm.ac.in,sahu.bichismita@gmail.com

Research Interest

Design and synthesis of Peptides and Modified Peptide Nucleic Acids (PNAs) for therapeutic and diagnostic applications. Design and synthesis of Bio-inspired hybrid molecular scaffolds and conjugates for Cancer, Metabolic and Neurological Disorder therapy. Development of new synthetic methodology and process chemistry for constructions of bio-active small molecules.

Experience

  • Jan 2019-Present:
    Assistant Professor, NIPER- Ahmedabad, Palaj, Gandhinagar
  • Oct 2018–Jan 2019:
    Consultant (Drug Discovery) KrishBioTech-Kolkata
  • Mar 2016- Aug 2018 :Manager (R&D-API ) ,ASolution Pharma, Ambernath, Mumbai
  • Jan 2015- Feb 2016:
    Scientist ,Laboratory for advanced research; KET, Mumbai .
  • Aug 2012-Oct 2014:
    Senior research scientist, Piramal Enterprises, Mumbai
  • Oct 2009-Aug 2011:
    Research scientist, Piramal Life Science Limited, Mumbai
  • Sept 2006-Aug 2009:
    Post Doctoral Fellow ,Carnegie Mellon University, Pittsburgh, USA

Honours/Awards/Grants/Consultancies

Honours/Awards

  • Team award- Piramal Life Science Ltd (PLSL), Mumbai-2011
  • Senior Research Fellowship (SRF) sponsored by Council of Scientific and Industrial Research (CSIR), India-2003
  • Junior Research Fellowship (JRF) sponsored by Council of Scientific and Industrial Research (CSIR), India-2001
  • Qualified All India level Graduate Aptitude Test in Engineering (GATE)-2001

Publications

  • Iulia Sacui , Wei-Che Hsieh , Arunava Manna ,BichismitaSahu , and Danith H. Ly "Gamma peptide nucleic acids: As orthogonal nucleic acid recognition codes for Organizing molecular self-assembly” J. Am. Chem. Soc., 2015, 137 (26), 8603–8610
  • Venkatasubbaiah A Venkatesha, Asavari A Joshi, Magesh Venkataraman, Vinay Sonawane, Prashant K Pandey, Julie Bose, Sarika A Choudhari, Dimple Bhatia, Ankita Srivastava, Vaibhavi Lad, Parkash Gill, Ramachandra Sangana, Tausif Ahmed, Anagha Damre, Vijaykumar Deore, Bichismita Sahu, Sanjay Kumar, Somesh Sharma and Veena Agarwal "P7170, a novel inhibitor of mTORC1/mTORC2 and Activin Receptor- Like Kinase 1 (ALK1) inhibits the growth of Non Small Cell Lung Cancer” Molecular Cancer 2014, 13, 259
  • Sufi M. Thomas; Bichismita Sahu; Srinivas Rapireddy; Raman Bahal; Sarah E. Wheeler; Eva M. Procopio; Joseph Kim; Sonali C. Joyce; Sarah Contrucci; Yun Wang; Kira L. Lathrop; Simon Watkins; Jennifer R. Grandis; Bruce A. Armitage; Danith H. Ly "Antitumor Effects of EGFR Antisense Guanidine-basedPeptide Nucleic Acids in Cancer Models” ACS Chemical Biology (2013), 8(2), 345-352
  • Bichismita Sahu, Guddeangadi N. Gururaja, Anamitra Chatterjee, Bishwajit Ganguly, Shaikh M. Mobin, and Irishi N. N. Namboothiri "Generation and Trapping of a Cage Annulated Vinylidenecarbene and Approaches to Its Cycloalkyne Isomer” J. Org. Chem. 2012, 77(16), 6998-7004
  • BichismitaSahu , Iulia Sacui , Srinivas Rapireddy , Kimberly J. Zanotti , Raman Bahal , Bruce A Armitage , and Danith H. Ly "Synthesis and Characterization of Conformationally- Preorganized, MiniPEG-Containing gammaPNAs with Superior Hybridization Properties and Water Solubility” J. Org. Chem., 2011, 76 (14), 5614– 5627
  • Nilambari Yewalkar, Vijaykumar Deore, Amol Padgaonkar, Sonal monohar, Bichismita Sahu, Pramod kumar, Archana jalota-Badhwar, Kalpana S. Joshi, someshsharma and sanjaykumar "Development of novel inhibitors targeting HIF-1alpha towards anticancer drug discovery ” Bioorganic and medicinal Chemistry letters, 2010, 20, 6426-6429.
  • Gaofei He, Srinivas Rapireddy, Raman Bahal,Bichismita Sahu and Danith H. Ly "Strand- Invasion of Extended, Mixed-Sequence B-DNA by ?PNAs” J. Am. Chem. Soc 2009, 131 (34), 12088–12090.
  • Bichismita Sahu, Guddeangadi N. Gururaja, Shaikh M. Mobin, and Irishi N. N. Namboothiri "Facile Synthesis of ß-Tribromomethyl and DibromomethylenatedNitroalkanes via Conjugate Addition of Bromoform to Nitroalkenes” J. Org. Chem., 2009, 74 (6), 2601- 2604
  • Bichismita Sahu, Venugopal Chenna, Kira L. Lathrop, Sufi M. Thomas, Gerald Zon, Kenneth J. Livak, and Danith H. Ly "Synthesis of Conformationally Preorganized and Cell- Permeable Guanidine-Based ?-Peptide Nucleic Acids (?GPNAs)” J. Org. Chem., 2009, 74 (4), 1509-1516
  • Bichismita Sahu, R. Muruganantham, I. N. N. Namboothiri; "Synthetic and Mechanistic Investigations on the Rearrangement of 2,3-Unsaturated 1,4-Bis(alkylidene)carbenes to Enediynes” Eur. J. Org. Chem. 2007, 15, 2477-2489
Complete list

Book/Book Chapter/Patents/Peer Review Abstract

Patents

  • Ly, Danith H.; Rapireddy, Srinivas; Sahu, Bichismita; "Synthesis and characterization of conformationally preorganized, (R)-diethylene glycolcontaining ? - peptide nucleic acids with improved hybridization properties and water solubility” PCT Int. Appl. (2012), WO 2012138955 A2 20121011
  • Sanjay Kumar, Rajiv Sharma, Rabert Zahler, Bichismita Sahu "Substituted imidazoquinoline derivatives as kinase inhibitors” PCT Int. Appl. (2012), WO 2012007926 A1 20120119
  • Sharma, Rajiv; Jain, Arunkumar; Sahu, Bichismita; Singh, Deepak; Mali, Sunil "Preparation of heterocyclyl compounds as inhibitors of IL-17 and TNFa for the treatment of inflammatory diseases and autoimmune disorders” PCT Int. Appl. (2014), WO 2014181287 A1 20141113
  • Sharma, Rajiv, Sahu Bichismita, Mali Sunil, Singh Deepak, Kumar Pramod, Dawange Mahesh, Mistry Hitesh ". Preparation of ROR gamma modulators and therapeutic uses thereof” PCT Int. Appl. (2015) ,WO 2015145371 A1 20151001

Peer Review -Abstracts

  • Bahal, Raman ,; Rapireddy, Srinivas; Sahu, Bichismita; Ly, Danith H "Sequenceunrestricted Watson-Crick recognition of double helical B-DNA by ?PNA”Abstracts of Papers, 242nd ACS National Meeting & Exposition, Denver, CO, United States, August 28-September 1, 2011, BIOL-171
  • He, Gaofei; Rapireddy, Srinivas; Bahal, Raman; Sahu, Bichismita; Ly, Danith H. "Strand invasion of extended, mixed-sequence B-DNA by ?PNAs (?-peptide nucleic acids ”Abstracts of Papers, 240th ACS National Meeting, Boston, MA, United States, August 22-26, 2010, ORGN-757
  • Crawford, Matthew J.; Rapireddy, Srinivas; Sahu, Bichismita; Ly, Danith H " Sequencespecific Recognition of Structured, Pre-microRNA with Conformationally Preorganized miniPEG-? peptide nucleic acids ”Abstracts of Papers, 240th ACS National Meeting, Boston ,MA, United States, August 22-26, 2010, BIOL-94
  • Sahu, Bichismita, Bichismita; Mobin, Shaikh M.; Namboothiri, Irishi N. N. "One-pot synthesis of a - dibromomethylenated nitroalkanes via Michael addition of tribromomethyl carbanion to conjugated nitroalkenes” Abstracts of Papers, 232nd ACS National Meeting, San Francisco, CA, United States, Sept. 10-14, 2006, ORGN-956
  • I. N. N. Namboothiri, N. K. Meher, S. Chavan, Sahu, Bichismita, O. P. Oommen, T. L. Varghese, Reshmi and K. N. Ninan,Polycyclic "Hydrocarbons as High Energy-Density (HED) Fuels for Propulsion”, Proceedings of the 5th International High Energy Materials Conference and Exhibit, DRDL, Hyderabad, November 23-25, 2005
Presentations:
National : 02
International: 02
Go to Navigation