Ph.D. Jadavpur University, Kolkata, India, 2011
(National Doctoral Fellow, AICTE, Govt. of India)

Dr. Pinaki Sengupta

Assistant Professor

Tele : 079-66745555

E-mail : pinakis@niperahm.ac.in

Research Interest

    The primary research area of Dr. Sengupta includes pharmacokinetic, toxicokinetic, metabolic profiling of chemical entities in discovery and formulation development phase; Analytical and Bioanalytical method development, validation using HPLC, UPLC, LC-MS/MS; Impurity profiling, compatibility and stability analysis of pharmaceuticals.

Experience

  • September 2017 – Present:
    Assistant Professor, Department of Pharmaceutical Analysis, NIPER Ahmedabad, Gujarat, India.
  • July 2016 – August 2017
    Assistant Professor, Department of Pharmaceutical Technology, International Islamic University Malaysia, Pahang, Malaysia.
  • July 2014 - June 2016:
    Senior Lecturer and Head of the Department, Pharmaceutical Chemistry, Faculty of Pharmacy, Lincoln University College, Selangor, Malaysia.
  • March 2011 – June 2014:
    Senior Executive, Analytical Development, Quality Control department, Fresenius Kabi Oncology Ltd, India.
  • November 2007 – February 2011:
    SRF-AICTE, Bioequivalence Study Centre, Jadavpur University, India.
  • July 2006 – October 2007:
    Junior Scientist, Drug Metabolism and Pharmacokinetics department, Discovery Research division, Dr. Reddys Lab Ltd., India.

Honours/Awards/Grants/Consultancies

Awards

  • ‘Professor Anupam Sengupta Memorial Medal’ for academic excellence in Pharmaceutical Chemistry in M. Pharm awarded by Jadavpur University, India (2006).
  • ‘Best Oral Presentation Award of ICCE, Thailand’ in International Congress of Chemistry and Environment Conference (ICCE) at Ubonrathchathani, Thailand (2010).
  • National Doctoral Fellowship (NDF) awarded by All India Council for Technical Education (AICTE), India (2009).
  • UGC Research Fellowship in Science for Meritorious Students awarded by University Grant Commission (UGC), India (2008).
  • UGC Scholarship for pursuing M. Pharm., awarded by University Grant Commission (UGC), India (2004).

Grants

  • Title: Naso-mucosal absorption of neuronal drug by sol-to-gel delivery system to target brain: approach to dose reduction.
  • Tenure: 2 years 2 months.
  • Funded by: Ministry of Higher Education, Govt. of Malaysia, Fundamental Research Grant Scheme (FRGS).
  • Title: Evaluation of safety profile of a Fixed dose combination of Antidiabetic and Antihypertensive drug by toxicity profiling and pharmacokinetic interaction study.
  • Tenure: 2 years
  • Funded by: Ministry of Higher Education, Govt. of Malaysia, Fundamental Research Grant Scheme (FRGS).
  • Title: Optimization of asiaticoside purification from Centella asiatica extract and development of asiaticoside gel formulation for topical application.
  • Tenure:1 year
  • Funded by: IIUM, Govt. of Malaysia, Research Initiative Grant Scheme (RIGS).
  • Title: Aqueous gel based topical nanoemulsion; An approach to enhance the bioavailability of lipophilic drugs.
  • Tenure:1 year
  • Funded by: IIUM, Govt. of Malaysia, Research Initiative Grant Scheme (RIGS).

Consultancies

  • Consultant for IIUM Bioequivalence Study Centre (iBEST), 25200 Kuantan, Pahang, Malaysia.

Publications

  • Sonali Jain, Heena Jariyal, Akshay Srivastava and Pinaki Sengupta*. Target Specific Intracellular Quantification of Etoposide by Quadrupole-Time of Flight based Mass Spectroscopic Method. Journal of Chromatography B, 2020, 1152, 122233. Impact Factor: 3.004.
  • Akhila Pyaram, Madhuri Rampilla, Jayshri Deore and Pinaki Sengupta*. Challenges and strategies for quantification of drugs in the brain: current scenario and future advancement. Critical Reviews in Analytical Chemistry. Critical Reviews in Analytical Chemistry, 2020, https://doi.org/10.1080/10408347.2020.1791041. Impact Factor: 4.568.
  • Pooja Dhakne, Amit Kumar Sahu, Manish Kumar Sharma, Pinaki Sengupta*. Simultaneous quantification of abemaciclib and letrozole in rat plasma: method development, validation and pharmacokinetic application, Biomedical Chromatography, 2020, 34, e4825. Impact Factor: 1.728.
  • Amit Kumar Sahu, Pinaki Sengupta*. Time of flight mass spectrometry based in vitro and in vivo metabolite profiling of ribociclib and their toxicity prediction. Journal of Chromatography B, 2020, 1147, 122142. Impact Factor: 3.004
  • Manish Kumar Sharma, Rajeshwari Rathod, Pinaki Sengupta*. Mass spectrometry based rapid quantitative bioanalysis of flibanserin; pharmacokinetic and brain tissue distribution study. Journal of Analytical Toxicology, 2020, 44 (6), 559–569. Impact Factor: 3.513
  • Manish Kumar Sharma, Ravi P. Shah, Pinaki Sengupta*. Amalgamation of Stress Degradation and Metabolite Profiling in Rat Urine and Feces for Characterization of Oxidative Metabolites of Flibanserin using UHPLCQ-TOF-MS/MS, H/D Exchange and NMR Technique. Journal of Chromatography B, 2020, 1139, 121993. Impact Factor: 3.004.
  • Dhruvisha Pokar, Niraj Rajput, Pinaki Sengupta*. Industrial approaches and consideration of clinical relevance in setting impurity level specification for drug substances and drug products. International Journal of Pharmaceutics. 2020, 576, 119018. Impact Factor: 4.845.
  • Maria Bandookwala, Disha Thakkar, Pinaki Sengupta*. Advancement in analytical strategies for quantification of the multifaceted nitroxidative stress biomarker 3- Nitrotyrosine in biological matrices. Critical Reviews in Analytical Chemistry, 2020, 50 (3), 265-289. Impact Factor: 4.568.
  • . Tarang Jadav, Sonali Jain, Kiran Kalia, and Pinaki Sengupta*. Current Standing and Technical Guidance on Intracellular Drug Quantification: A New Site Specific Bioavailability Prediction Approach. Critical Reviews in Analytical Chemistry, 2020, 50 (1), 50-61. Impact Factor: 4.568.
  • Priyanka Lohar, Manish Kumar Sharma, Amit Kumar Sahu, Rajeswari Rathod, Pinaki Sengupta*. Simultaneous bioanalysis and pharmacokinetic interaction study of Acebrophylline, Levocetirizine and Pranlukast in Sprague Dawley rat. Biomedical Chromatography, 2019, 33: e4672. Impact Factor: 1.728
Complete list

Books/Book Chapters/Patents/Peer Review -Abstracts

Books

  • Title: Synthesis, anticancer and antimicrobial potential of oxadiazoles.Publisher: Lambert Academic Publishing, Germany.
  • ISBN: 978-3-330-01006-2
  • Date published: 17th November, 2016.

Book Chapter

  • Pharmacokinetic and subchronic toxicity study of a fixed dose combination and a sustained release tablet.

Patents

  • Title: A pharmaceutical composition comprising a combination of pioglitazone and telmisartan.
  • Country: Malaysia.
  • Filing year: 2017.
  • Patent application No.: PI2017400011
  • Title: A method of preparing a pharmaceutical composition comprising telmisartan.
  • Country: Malaysia.
  • Filing year: 2018.
  • Patent application No.: PI2018702925

Peer Review Abstract

  • Establishment of a Stability Indicating RP-HPLC Assay Method for Quantitative Determination of Binimetinib and Characterization of Its Major Degradants by LC-MS/MS. Applied Pharmaceutical Analysis (APA) – India, Boston Society, 2020.
  • Synthesis and Structural Elucidation of N- Formylated Degradation Product of Ribociclib. Applied Pharmaceutical Analysis (APA) – India, Boston Society, 2020.
  • Rapid determination of flibanserin in rat plasma and brain by a validated UPLC-MS/MS method. National Seminar on Pharmaceutical Analysis, Nirma University, Ahmedabad, India, 2019.
  • In silico metabolite prediction and in vitro metabolite identification of avanafil by UHPLC-QTOF -MS/MS. Third SSX India 2018 conference, Indian Institute of Science (IISc), Bangalore, India, 2018.
  • Rapid identification and structural characterization of the in vitro metabolites of Flibanserin using UHPLC– QTOF MS/MS. Third SSX India 2018 conference, Indian Institute of Science (IISc), Bangalore, India, 2018.
  • Development and validation of a bioanalytical method for simultaneous quantification of acebrophylline, levocetrizine and pranlucast in rat plasma by RP-HPLC. APA India 2018, Pune, 2018.
  • Physicochemical characterization and metabolism site prediction of NIPER1517MC01AR04 using computational and experimental methods. CPSBT-2018, Ahmedabad, 2018.
  • Physicochemical characterization of boronic acid derivative AMS-AZ-13 by computational and experimental methods. CPSBT-2018, Ahmedabad, 2018.
  • Physicochemical characterization of NIPER1416MCRT16 using computational and experimental methods. CPSBT-2018, Ahmedabad, 2018.
  • Comparison of extraction techniques in preparation of rat plasma samples for bioanalytical study of eluglustat. CPSBT-2018, Ahmedabad, 2018.
  • An insight on extractables and leachables profiling from pharmaceutical packaging components: A review on current analytical techniques. CPSBT-2018, Ahmedabad, 2018.
  • Development and validation of bioanalytical method for NIPERAMCD1214JKAF, a potent anti-diabetic agent: application to pharmacokinetic study. CPSBT-2018, Ahmedabad, 2018.
  • Development of a stability indicating RP-HPLC method for trimethobenzamide by QbD approach. CPSBT-2018, Ahmedabad, 2018.
  • Formulation of a nanoemulsion for topical delivery of raloxifene. 31st Malaysian Society of Pharmacology and Physiology conference, 2017, Kelantan, Malaysia.
  • Physical characterization of a developed raloxifene nanoemulsion formulation. 4th Pahang State Pharmacy Research and Development Convention, 2017, Kuantan, Malaysia.
  • Development and validation of a LC- MS/MS method for simultaneous quantitation of telmisartan and pioglitazone in rat plasma. 2nd International Conference on Industrial Pharmacy, 2016, Kuantan, Malaysia.
  • Beneficial Alteration of Blood Biochemical Parameters by Telmisartan-Pioglitazone Combination in Rat. 2nd International Conference on Industrial Pharmacy, 2016, Kuantan, Malaysia.
  • Evaluation of safety profile of a fixed dose combination of pioglitazone and telmisartan in terms of oral subchronic toxicity study in rat. 4th International Conference on Pharmaceuticals, Nutraceuticals and Cosmetic Science, 2015, Melaka, Malaysia.
  • Stability Indicating RP-HPLC method for simultaneous determination of Tramadol hydrochloride and Aceclofenac in dosage form. 12th MPS Pharmacy Scientific Conference, 2015, Kualalumpur, Malaysia.
  • Phytochemical and toxicity study of standardized extract of Epipremnum aureum in rodents. 12th MPS Pharmacy Scientific Conference, 2015, Kualalumpur, Malaysia.
  • Development and Validation of a LC-MS/MS Method for Simultaneous Quantitation of Olmesartan and Pioglitazone in Human Plasma. Special Issue of Research Journal of Chemistry and Environment, International Congress of Chemistry and Environment Conference, Jan 2010, Ubonrathchathani, Thailand.
  • Comparative Bioequivalence Study of Levofloxacin Tablets in Healthy Indian Volunteers. 62 Indian Pharmaceutical Congress, 2010, Ahmedabad, India.
  • Development and Validation of Method for Quantitation of Amisulpride in Human Plasma. Special Issue of Research Journal of Biotechnology, 1st International Society BioTechnology Conference, Dec 2008, Gangtok, Sikkim, India.
  • Simultaneous Quantitation of Rosiglitazone and Glibenclamide in Human Plasma by LC-MS/MS; Method Development and Validation. Special Issue of Research Journal of Biotechnology, 1st International Society BioTechnology Conference, Dec 2008, Gangtok, Sikkim, India.
  • Evaluation of anticancer and antimicrobial activity of 1, 3, 4-oxadiazole derivatives. 59 Indian Pharmaceutical Congress, 2007, Varanasi, India.
Presentations:
National : 09
International: 16
Projects:
Completed 04
Ongoing 00
PhD:
Completed 01
Ongoing 03
MS Dissertation:
Completed 21
Ongoing 06
Go to Navigation