Abhijeet S. Kate, Ph. D

Ph.D. Florida Atlantic University, USA 2008

Abhijeet S. Kate Ph.D.

Associate Professor

Tele :+79 66745555

E-mail : abhijeetk@niperahm.ac.in , kate.abhi.s@gmail.com

Research Interest:

  • Bio-prospecting of endolichenic fungi to discover novel bioactive scaffolds.
  • Implementation of various LC-MS based dereplication strategies to discover novel scaffolds from biological sources such as marine and terrestrial bacteria, fungi and plants.
  • Downstream process optimization for large scale isolation of Natural Products.
  • Fingerprinting of extracts by LC-UV-MS in Natural Products based drug discovery program.
  • Development of novel approaches for the separation and characterization of marine and terrestrial natural products to accelerate the discovery of drug leads.

Experience:

  • December 2019 - Present:
    Associate Professor, NIPER-Ahmedabad, Palaj, Gandhinagar
  • July 2017 - December 2019:
    Assistant Professor, NIPER-Ahmedabad, Palaj, Gandhinagar
  • December 2014 – July 2017:
    Senior Scientist, SABIC Research and Technology Center ,Bangalore
  • January 2010 –November 2014:
    Group Leader, Piramal Life Science Limited, Mumbai
  • July 2008 – December 2009:
    Application Engineer, Agilent Technologies, Bangalore
  • September 2006 – April 2008:
    Research Associate, University of Prince Edward Island, Charlottetown, PEI, Canada
  • February 2003 – June 2004:
    Group Leader, Enem Nostrum Remedies Pvt. Ltd. ,Mumbai
  • July 2000 – January 2003:
    Analytical chemist, Medlar laboratories Pvt. Ltd. ,Mumbai

Honours/Awards/Grants/Consultancies:

  • Selected to work on DBT-Piramal funded Mega Project "Screening of Biomolecules from microbial diversity collected from different ecological niches – Part II chemical characterization”
  • Awarded research funding from Florida Atlantic University during Ph.D. program
  • Recipient of "Gold Medal” in Chemistry and "Silver Medal” in Mathematics during B.Sc. (University topper in chemistry and mathematics)

Publications:

  • Chilamula, S., Pandey, K., Malpure, N.V., Chatterjee, D., Raut, P.S., Sirigineedi, P., Bairwa, K. and Kate, A.S., 2020. Isolation and Identification of Pinocembrin-7-O-[4”, 6"-(S)-Hexahydroxy Diphenoyl]-β-D-Glucose from Macrosolen capitellatus: In vitro and In silico Studies to Explore its Anticancer Potential. Journal of Biologically Active Products from Nature, 10(3), pp.177-182.
  • Pandey, K., Shevkar, C., Bairwa, K. and Kate, A.S., 2020. Pharmaceutical perspective on bioactives from Alstonia scholaris: ethnomedicinal knowledge, phytochemistry, clinical status, patent space, and future directions. Phytochemistry Reviews, pp.1-43.
  • Niguram, P., Goswami, A. and Kate, A.S., 2020. A novel hydrophilic interaction liquid chromatography method for the analysis of arterolane; Isolation and structural elucidation of its major degradation product by LC-HRMS and NMR. Journal of Pharmaceutical and Biomedical Analysis, p.113279.
  • Thakkar, D. and Kate, A.S., 2020. 1-(Benzo [b] thiophen-4-yl) piperazine Ring Induced Bioactivation of Brexpiprazole in Liver Microsomes: Identification and Characterization of Reactive Conjugates Using Ultra-High-Performance Liquid Chromatography/Quadrupole Time-of-Flight Mass Spectrometry. European Journal of Drug Metabolism and Pharmacokinetics, pp.1-11.
  • Niguram, P., Polaka, S.N., Rathod, R., Kalia, K. and Kate, A.S., 2020. Update on compatibility assessment of empagliflozin with the selected pharmaceutical excipients employed in solid dosage forms by thermal, spectroscopic and chromatographic techniques. Drug Development and Industrial Pharmacy, 46(2), pp.209-218.
  • Thakkar, D. and Kate, A.S., 2020. Update on metabolism of abemaciclib: In silico, in vitro, and in vivo metabolite identification and characterization using high resolution mass spectrometry. Drug Testing and Analysis, 12(3), pp.331-342.
  • Patil, S.P., Goswami, A., Kalia, K. and Kate, A.S., 2020. Plant-Derived Bioactive Peptides: A Treatment to Cure Diabetes. International Journal of Peptide Research and Therapeutics, 26(2), pp.955-968.
  • Parkhe, A., Parekh, P., Nalla, L.V., Sharma, N., Sharma, M., Gadepalli, A., Kate, A. and Khairnar, A., 2020. Protective effect of alpha mangostin on rotenone induced toxicity in rat model of Parkinson’s disease. Neuroscience Letters, 716, p.134652.
  • Naidu, K.S., Kate, A.S., Kshirsagar, V., Ganeshan, R., Gunale, T., Zhou, B., Anapat, S., Sulub, Y., Kumar, A. and Rao, N., 2020. A spectrophotometric method for estimation of titanium alkoxide, a catalytically active form of titanium in oligomer/polymers. Polymer Testing, 86, p.106446.
  • Thakkar, D. and Kate, A.S., 2019. In silico, in vitro and in vivo metabolite identification of brexpiprazole using ultra high performance liquid chromatography/quadrupole time‐of‐flight mass spectrometry. Rapid Communications in Mass Spectrometry, 33(11), pp.1024-1035.
  • Niguram, P. and Kate, A.S., 2019. Structural characterization of forced degradation products of empagliflozin by high resolution mass spectrometry. Journal of Liquid Chromatography & Related Technologies, 42(13-14), pp.417-428.
  • Gohil, A.R., Deshmukh, S.K., Bhattacharya, V., Lavhale, R., Verekar, S. and Kate, A.S., 2019. Exophiarin, an isocoumarin from the fungus Exophiala sp. with antihyperglycemic activity. Natural Product Research, pp.1-9.
  • Kate, A.S. and Basavaraju, K.C., 2018. A simple potentiometric titration method for estimation of maleic anhydride in high molecular weight styrene-maleic anhydride copolymer. Polymer Testing, 65, pp.369-373.
  • Thakkar, C.S., Kate, A.S., Desai, D.C., Ghosh, A.R. and Kulkarni-Almeida, A.A., 2015. NFAT-133 increases glucose uptake in L6 myotubes by activating AMPK pathway. European journal of pharmacology, 769, pp.117-126.
  • Shah, M., Deshmukh, S.K., Verekar, S.A., Gohil, A., Kate, A.S., Rekha, V. and Kulkarni-Almeida, A., 2015. Anti-inflammatory properties of mutolide isolated from the fungus Lepidosphaeria species (PM0651419). SpringerPlus, 4(1), p.706.
  • Rahier, N.J., Molinier, N., Long, C., Deshmukh, S.K., Kate, A.S., Ranadive, P., Verekar, S.A., Jiotode, M., Lavhale, R.R., Tokdar, P. and Balakrishnan, A., 2015. Anticancer activity of koningic acid and semisynthetic derivatives. Bioorganic & Medicinal Chemistry, 23(13), pp.3712-3721.
  • Kate, A.S., Richard, K., Ramanathan, B. and Kerr, R.G., 2010. A halogenated pseudopterane diterpene from the Bahamian octocoral Pseudopterogorgia acerosa. Canadian Journal of Chemistry, 88(4), pp.318-322.
  • Kate, A.S., Kohl, A.C. and Kerr, R.G., 2010. A simple and sensitive APCI-LC-MS method for the detection of the antitumor agent, carmustine (BCNU) in rat plasma. Journal of Liquid Chromatography & Related Technologies, 33(6), pp.818-824.
  • Kate, A.S., Pearson, J.K., Ramanathan, B., Richard, K. and Kerr, R.G., 2009. Isolation, biomimetic synthesis, and cytotoxic activity of bis (pseudopterane) amines. Journal of natural products, 72(7), pp.1331-1334.
  • Kate, A.S., Aubry, I., Tremblay, M.L. and Kerr, R.G., 2008. Lipidyl pseudopteranes A− F: isolation, biomimetic synthesis, and PTP1B inhibitory activity of a new class of pseudopteranoids from the gorgonian Pseudopterogorgia acerosa. Journal of natural products, 71(12), pp.1977-1982.
  • Ibrahim, A.S., Kate, A. and Kerr, R., 2008. INVESTIGATION OF THE BIOSYNTHETIC ORIGIN OF THE DITERPENES IN GORGONIAN Pseudopterogorgia acerosa. JASMR, 3(2), pp.177-184.

Book/Book Chapter/Patents/Peer Review Abstract

Patents

  • USE OF A THIOPEPTIDE COMPOUND IN THE TREATMENT OF CLOSTRIDIUM DIFFICILE ASSOCIATED INFECTIONS: Mahajan Girish ,Kate Abhijeet,Sudhir, Ranadive Prafull, Chadha Bhupinder Singh, Shouche Yogesh, Purohit Hemant, Balakrishnan Arun, PCT Application No.: PCT/IB2014/065702, 30.10.2014
  • MACROCYCLIC LACTONE DERIVATIVES AND USES THEREOF: HARIHARAN Sivaramakrishnan ,Kate AbhijeetSudhir, THOMAS Becky Mary, KULKARNI-ALMEIDA Asha, TRIVEDI Jacqueline Vinodkumar, JADHAV Mahesh Gundaji, SHAH, Meet, PCT application No. : PCT/IB2014/058693, 31.01.2014
  • NUCLEOSIDE ANALOGUE AS AN ANTICANCER COMPOUND: Kate Abhijeet Sudhir, GEORGE Saji David, SONAWANE Shailendra, PERIYASAMY, Giridharan; PCT Application No.: PCT/IB2013/052481, 03.10.2013
Presentations:
National : 01
International: 02
Projects:
Ongoing 01
Ph. D
Ongoing 05
MS Dissertation:
Completed: 12
Ongoing: 04
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