Research

Thrust areas: Diabetes and Obesity, Infectious diseases, Cancer, Cardiovascular diseases and Neuronal disorders

Diabetes and Obesity:

  • Proteomics and genomics biomarkers for diabetes and its microvascular complications
  • Lead based design and development of NCEs of natural pharmacophores as anti-diabetic and anti-obesity leads
  • Stabilized lipid vesicular formulation for oral delivery of therapeutic proteins and peptides (Insulin and peptidic incretin hormones such as GLP-1, exendin-4)
  • PK-PD herb-drug interaction studies for therapeutic modulation in diabetes

Infectious diseases:

  • Novel and targeted drug delivery systems such as dissolvable biodegradable polymeric transdermal microneedle arrays for drug delivery in HIV infections
  • Translingual formulation for treatment against onycomychosis infection
  • Design and synthesis of small molecule heterocycles targeting redox machinery of infectious bacteria
  • Target Oriented Synthesis (TOS) based development of New Chemical Entities (NCEs) of natural scaffolds against Multi Drug Resistant Tuberculosis and its secondary complications
  • Diversity Oriented Synthesis (DOS) of small molecules as anti-HIV leads

Cancer:

  • SNPs and its role in oral cancer in Western Indian population
  • Structure-based drug design, synthesis and screening of small molecules, including pro-apoptotic BAX activators
  • Thiazole heterocyclic chemical probes and their screening for lung cancer
  • Stabilized lipid vesicular formulation for oral delivery of therapeutic proteins and peptides (Buserelin, Abarelix) for prostate cancer and uterine cancer
  • Exploring marine algae in search of new leads for treatment of breast cancer and lung cancer
  • Cancer stem cell (CSC) re-differentiation, regime for prevention of relapse
  • Discovery of new natural products as leads for lung cancer

Cardiovascular diseases:

  • Novel and targeted drug delivery systems for angina
  • Development of tri-layered tablet formulation for controlled delivery of antihypertensives
  • Development of bio-degradable stents and coatings

Neuronal disorders:

  • Role of JAK pathway Alzheimer’s disease
  • Modulation of microgilal phenotype in neuroinflammation in cerebral ischemia
  • Melatonin in traumatic brain injury
  • Discovery of new natural products as neuroprotective leads

Other areas:

  • Cartilage regeneration by using biodegradable nano-fibre scaffolds
  • Osteoconductive coatings for orthopaedic implants
  • Bioactive bone grafts for bone regeneration
  • Induced pluripotent stem cells

The dedicated faculty at NIPER-G investigates different aspects of human health such as diabetes, tuberculosis, obesity, cancer, neurologic disorders. Research is being conducted across the spectrum

  • Proteomics and genomic biomarkers, pharmacogenomics and stem cell research
  • Drug discovery and development using molecular modeling
  • Drug discovery from natural sources
  • Targeted drug delivery system, solid state characterization, QbD in formulation
  • Analytical/bioanalytical method development and impurity profiling
  • Development of biomaterial for cardiovascular, orthopedic and ocular implants
  • Metal toxicology, neurodegeneration, Cognition

We believe in exploring multidisciplinary research in all departments and help the student to excel in their field and develop the skills.

NIPER has been actively pursuing the research in different departments

Research Projects

On Going

Project Title Principal Investigator Sponsoring Agency Year
Bio-engineered three-dimensional stem cell niche for intervertebral Disc repair and regeneration Dr.Akshay Srivastava DST SERB 2016-2017
Regulatory non-coding RNA mediated mesenchymal stem cell engineering: A safety and efficacy study in rodent model of ischemic stroke Dr.Pallab Bhattacharya DST SERB 2016-2017
Mitochondrial protection in ischemic stroke by using microRNA mediated engineered stem cells. Dr.Pallab Bhattacharya ISN,USA
Dissecting Brain Reward Circuitry & CNS Comorbidities in Chronic Neuropathic Pain . Dr.Vinod Tiwari DST SERB 2016-2017
Aptamer targeted dendronized polymeric nanoparticles to deliver Anti-miRNA for treatment of Triple Negative Breast Cancer Dr Rakesh Tekade DST, SERB India 2016-2017
Triple punch approach for triple negative breast cancer by delivering siRNA and doxorubicin using graphene oxide wrapped polymeric nanoparticles Dr Rakesh Tekade DST, SERB India 2016-2017
A novel strategy to explore endosomal degradation of gene therapeutics Dr Rakesh Tekade Fundamental Research Grant Scheme, Ministry of Health, Malaysia. 2016-2017
Synthesis and development of antitubercular 1,4-naphthoquinone congeners asMycobacterium tuberculosis methionine aminopeptidases inhibitors Dr. Anita Mahapatra
Dr. Neelam Chauhan (Co-PI)
DBT 2013-2016
In-situ gelling mucoadhesive system for brain delivery of p-Glycoprotein (P-gp) substrates via nasal route: Effect of a novel lipidic agent on drug release and P-gp inhibition Dr. Manju Misra DST, INSPIRE 2012-2017

Completed

Project Title Principal Investigator Sponsoring Agency Year
Design of Oral delivery system for macromolecules using gastrointestinal patch system: Role of fatty acid as penetration enhancer Dr. Manju Misra DBT, RGYI 2012-2015
A non-viral vector for inducing pluripotency Dr. Neelam Chauhan DBT, RGYI 2010-2012
A non-viral vector for inducing pluripotency Dr. Neelam Chauhan GSBTM 2010-2012
Biotech pharma link unit for converting biological therapeutics into dosage forms for SMEs Dr. Neelam Chauhan (Co-PI) IC, Govt. of Gujarat 2009-2011
Centre of Excellence for Quality Assurance of Drugs Dr. Anita Mahapatra IC, Govt. of Gujarat 2009-2011

Publications

2017

2017

  • Gorain, B., Tekade, M., Kesharwani, P., Iyer, A.K., Kalia, K., and Tekade, R.K. (2017). The use of nanoscaffolds and dendrimers in tissue engineering. Drug discovery today, pii: S1359-6446(16)30489-5 [Impact Factor: 5.7].
  • Tambe, V., Thakkar, S., Raval, N., Sharma, D., Kalia, K., and Tekade, R.K. (2017). Surface Engineered Dendrimers in Sirna Delivery and Gene Silencing. Current pharmaceutical design [Impact Factor: 3.5].
  • Sharma D, Bhattacharya P, Kalia K, Tiwari V. Diabetic nephropathy: New insights into established therapeutic paradigms and novel molecular targets. Diabetes Research and Clinical Practice, 128: 91–108 (2017). [Impact Factor: 3.045]
  • Vurugonda U, Rednam P J, Sinha M. Development of biodegradable scaffold using polylactic acid and polycaprolactone for cardiovascular application. International journal of Polymeric Materials and Polymeric Biomaterials, in press DOI: 1080/00914037.2017.1297945 (IF 1.67)
  • Viral Shah, Bijaya Krushna Choudhary, "Fabrication , Physicochemical Characterization and performance Evaluation of Biodegradable polymeric microneedle patch system for enhanced transcutaneous flux of high moleculer weight therapeutics" accepted for publication in American Association of Pharmaceutical scientists, Pharm. sci. tech. Journal, Springer publisher.
    DOI: 10.1208/s12249-017-0774-5
  • Shreya Thakkar, Viral Shah, Manju Misra, Kiran Kalia, "Nanocrystal Based Drug Delivery System: Conventional and Current Scenario" accepted for publication in "Recent Patents on Nanotechnology". accepted in Recent patents on nanotechnology.
    DOI: 10.2174/1872210510666161014122439
  • Pardhi, T.; Vasu, K. Identification of dual kinase inhibitors of CK2 and GSK3beta: combined qualitative and quantitative pharmacophore modeling approach. J. Biomol.
    Struct. Dyn. 2017, 1-18.

2016

2016

  • Patel, MS, Shah, HS, Shrivastava, N (2016) c-Myc Dependent Cell Competition in Human Cancer Cells. Journal of Cellular Biochemistry.
  • Shah, H, Patel, M, Shrivastava, N (2016) Gene expression study of phase I and II metabolizing enzymes in RPTEC/TERT1 cell line: application in in vitro nephrotoxicity prediction. Xenobiotica: 1-7.
  • Gorain, B., Choudhury, H., Tekade, R.K., Karan, S., Jaisankar, P., and Pal, T.K. (2016). Comparative biodistribution and safety profiling of olmesartan medoxomil oil-in-water oral nanoemulsion. Regulatory toxicology and pharmacology, 82, 20-31 [Impact Factor: 2.4].
  • Choudhury, H., Gorain, B., Chatterjee, B., Mandal, U.K., Sengupta, P., and Tekade, R.K. (2016). Pharmacokinetic and Pharmacodynamic Features of Nanoemulsion Following Oral, Intravenous, Topical and Nasal Route. Current pharmaceutical design [Impact Factor: 3.5].
  • Ghanghoria, R., Kesharwani, P., Tekade, R.K., and Jain, N.K. (2016). Targeting luteinizing hormone-releasing hormone: A potential therapeutics to treat gynecological and other cancers. Journal of controlled release : official journal of the Controlled Release Society, pii: S0168-3659(16)31169-5, [Impact Factor: 7.5].
  • Dua, K., Shukla, S.D., Tekade, R.K., and Hansbro, P.M. (2016). Whether a novel drug delivery system can overcome the problem of biofilms in respiratory diseases? Drug delivery and translational research, 7(1):179-187 [Impact Factor: 1.9].
  • Ghanghoria, R., Tekade, R.K., Mishra, A.K., Chuttani, K., and Jain, N.K. (2016). Luteinizing hormone-releasing hormone peptide tethered nanoparticulate system for enhanced antitumoral efficacy of paclitaxel. Nanomedicine (London, England) 11, 797-816 [Impact Factor: 4.9].
  • Soni, N., Soni, N., Pandey, H., Maheshwari, R., Kesharwani, P., and Tekade, R.K. (2016). Augmented delivery of gemcitabine in lung cancer cells exploring mannose anchored solid lipid nanoparticles. Journal of colloid and interface science 481, 107-116 [Impact Factor: 3.5].
  • Tekade, R.K., Tekade, M., Kesharwani, P., and D'Emanuele, A. (2016). RNAi-combined nano-chemotherapeutics to tackle resistant tumors. Drug discovery today, 21(11):1761-1774 [Impact Factor: 5.7].
  • Jarial R, Thakur S, Sakinah M, Zularisam A W, Sharad A, Kanwar S S, Singh L.*Potent anticancer, antioxidant and antibacterial activities of isolated flavonoids from Asplenium nidus. Journal of King Saud University – Science (In Press).
    doi.org/10.1016/j.jksus.2016.11.006. (2016). [Impact Factor: 1.2]

2015

2015

  • Anita Mahapatra*, N. Lunagariya and R. Agarwal Rajput, Induction of apoptosis by zerumbone and its derivatives on human lung cancer cells(2015), Natural Product Communications, (Accepted)
  • Anita Mahapatra*, P. Shah, M. Jivrajani and M. Nivsarkar, Synthesis and blastocyst implantation inhibition potential of lupeol derivatives in female mice, (2015), Records of Natural Products 9 (4), 561-566. Impact Factor: 1.560
  • Exploring mixing uniformity of a pharmaceutical blend in a high shear mixture granulator using enthalpy values obtained from DSC Ekta Bharvada, Viral Shah, Manju Misra Powder Technology 05/2015; 276. DOI:10.1016/j.powtec.2015.02.008 · 2.27 Impact Factor

2014

2014

  • A Mahapatra, P. Shah, M. Jivrajani and M. Nivsarkar, Synthesis and blastocyst implantation inhibition potential of lupeol derivatives in female mice, (2014), Records of Natural Products (Accepted) Impact Factor: 1.560
  • S. Jansari, N. Devashri, A. Dhanani, N. Chauhan. Differentiation of stem cells into pancreatic β-cells: regenerative medicine for diabetes, 5: 901-9 (2014) Impact Factor: 1.34
  • A. Mahapatra, V. Maheswari, N. P. Kalia, V. S. Rajput and I. A. Khan, Synthesis and Antitubercular Activity of Berberine Derivatives. (2013), Chemistry of Natural Compounds 50(2), 321-325. Impact Factor: 1.029
  • N. Chauhan, H. Padh. Intra and inter ethnic variations for NAT2 polymorphisms. African Journal of Biotechnology 13: 4639-46 (2014) Impact Factor: 0.57
  • A. Mahapatra, N. Chauhan, D. R. Patel, N. P. Kalia, V. S. Rajput and I. A. Khan, 2013, Synthesis and antitubercular activity of oleanolic acid analogues, Pharmaceutical Chemistry Journal 48(1), 39-43. Impact Factor: 0.373
  • D. Bhatt, N. Chauhan, A. Sharma, D. Dhawan, R. Bhatt, S. Phatak, H. Padh. Plasma glucose concentration as a phenotypic marker for CYP2C9 genetic variants in diabetic population of Gujarat. Indian Journal of Pharmaceutical Sciences, 76: 72-77 (2014) Impact Factor: 0.63.
  • R. Khabiya, D Upadhyay, A Srivastava, S. Anandjiwala (2014) Simultaneous quantification of three bioactive Lignans viz. Phyllanthin, Hypophyllanthin and Niranthin from Phyllanthus amarus using HPTLC. Journal of Planar Chromatography - Modern TLC 4, 281-286. Impact Factor – 0.67
  • D. Patil, R P Dash, S K Thakur, A N. Pandya, P.Venkatesh, K K. Vasu, and M Nivsarkar Implication of novel thiazolo-thiophene derivative (MCD-KV-10) for management of asthma (2014) J Enzyme Inhibition and Med Chem. Impact Factor:2.38

2013

2013

  • S. Thakur, S. Anandjiwala, M. Nivsarkar. Ulcer protective effect of hydroalcholic extract of Bergia suffurticosa in rats’. Australian Journal of Herbal Medicine 2013; 25(2): 74-78.
  • D. Upadhyay, R. P. Dash, S. Anandjiwala, M. Nivsarkar. Comparative pharmacokinetic profiles of picroside I and II from kutkin, Picrorhiza kurroa extract and its formulation in rats. Fitoterapia 2013; 85: 76-83. Impact Factor: 1.848
  • S. Patil, R. P. Dash, S. Anandjiwala, M. Nivsarkar. Pharmacokinetic Study of Berberine from Rasont and Implication of Lysergol for Its Bioavailability Enhancement. Journal of Liquid Chromatography and Related Technologies, 2013; 36(3): 336-348. Impact Factor: 0.953
  • S. Patil, M. Nivsarkar, and S. Anandajiwala. Isolation and TLC Densitometric Quantification of Lysergol from the Seeds of Ipomoea muricata (Linn.) Jacq. ISRN Chromatography 2013, Article ID 134586, 6 pages.
  • D. Rathee, M. Thanki, S. Bhuva, S. Anandjiwala, R. Agrawal. Iridoid glycosides-Kutkin, Picroside I, and Kutkoside from Picrorrhiza kurroa Benth inhibits the invasion and migration of MCF-7 breast cancer cells through the down regulation of matrix metalloproteinases. Arabian Journal of Chemistry 2013; 6: 49-58. Impact Factor: 1.367

2012

2012

  • S. A. Chaudhary & A. F. Shahiwala, Directly compressible medicated chewing gum formulation for quick relief from common cold, International Journal of Pharmaceutical Investigation, 2012, 2(3),123-33.
  • S. A. Chaudhary, A. F. Shahiwala & M. Misra, Directly Compressible Medicated Chewing Gum (MCG)” for Staying Alert, Drug Development & Delivery, July-Aug 2012.
  • Jadhav H., Joshi A., Misra M., Shahiwala A., 2012. "Effect of Various Formulation Parameters on the Properties of Hydrogel Wound Dressings”. Drug Delivery Letters. 2, (4), 2012.
  • H. Jadhav, A. Joshi, M. Misra, Aliasgar Shahiwala. "Development of Nanostructured Silver Hydrogel Composites for Effective Treatment of Wounds”. Advanced Science, Engineering and Medicine. 4, 49-54 (2012).
  • S. Patil, R. P. Dash, S. Anandjiwala and M. Nivsarkar. Pharmacokinetic Study of Berberine from Rasont and Implication of Lysergol for Its Bioavailability Enhancement. Journal of Liquid Chromatography and Related Technologies 2012; (Accepted). (Impact Factor: 0.953)
  • H. Yadav, P. Mungara, M. Jivrajani, M. Nivsarkar and S. Anandjiwala. TLC-Densitometric Quantification of Negundoside, Ursolic Acid, Eugenol, Lupeol and β-sitosterol using HPTLC from Vitex negundo Leaves. Journal of Liquid Chromatography and Related Technologies 2012; (Article first published online: 23 Mar 2012 DOI:10.1080/10826076.2011.619044. (Impact Factor: 0.953)
  • S. Patil, R. P. Dash, S. Anandjiwala and M. Nivsarkar. Simultaneous quantification of berberine and lysergol by HPLC-UV: Evidence that lysergol enhances the oral bioavailability of berberine in rats. Biomedical Chromatography 2012; 26: 1170–1175. DOI: 10.1002/bmc.2674 (Impact Factor: 1.966)
  • B. Singh, J. R. Nadkarni, Ram A. Vishwakarma, S. B. Bharate, M. Nivsarkar, S. Anandjiwala. The hydroalcoholic extract of Cassia alata (Linn.) leaves and its major compound rhein exhibits antiallergic activity via mast cell stabilization and lipoxygenase inhibition. Journal of Ethnopharmacology 2012; 141: 469– 473. DOI:10.1016/j.jep.2012.03.012 (Impact Factor: 2.466)
  • P Bhise, A. Shahiwala, M Misra. "Mucoadhesive Nasal Delivery of Raloxifene: Effect of cyclodextrin Complexation and Chitosan Grades on Extent of Drug Loading and Release, Archives of Pharmacy Practice, Vol 3 (2),2012,136-143.
  • N. Bagul, A. Shahiwala, M. Misra. "Design and Development of Solid Self Emulsifying Osmotic Delivery System of Nifedipine" Archives of pharmacy practice. In publication Vol 3 (2)2012, 128-135.

2011

2011

  • Patil S., Pund S., Joshi A., Shishoo C. J., Shahiwala A., 2011. Chronomodulated press-coated pulsatile therapeutic system for aceclofenac: optimization of factors influencing drug release and lag time. ChronoPhysiology and Therapy,1, 1–10.
  • Rathee D, Thanki M, Agrawal R, Anandjiwala S. Isolation, Characterization and Simultaneous Quantification of Picroside I and Kutkoside using HPTLC from Picrorrhiza kurroa Benth. Journal of Liquid Chromatography & Related Technologies. 2011; 34: 360–374. DOI: 10.1080/10826076.2011.551607 (Impact Factor: 1.00)
  • T. Vyas, R. P. Dash, S. Anandjiwala, M. Nivsarkar. Formulation and pharmacokinetic.
  • Evaluation of hard gelatin capsule encapsulating lyophilized Vasa Swaras for improved stability and oral bioavailability of vasicine. Fitoterapia 2011; 82: 446-453.; doi:10.1016/j.fitote.2010.12.005. (Impact Factor: 1.363)
  • Jain V, S.K. Verma, S.S. Katewa, S. Anandjiwala and B. Singh. Free radical scavenging property of Bombax ceiba Linn. root. Res. J. Med. Plant. 2011; 5(4): 462-470. DOI: 10.3923/rjmp.2011.462.470.

2010

2010

  • S. A. Chaudhary & A. F. Shahiwala, Medicated chewing gum – a potential drug delivery system, Expert Opinion on Drug Delivery, 2010, 7 (7) , 871-885.
  • C. Kamaraj, A A Rahuman*, A Mahapatra*, A. Bagavan and G. Elango, Insecticidal and larvicidal activities of medicinal plant extracts against mosquitoes, (2010), Parasitology Research, 107, 1337-1349. . Impact Factor: 2.149
  • Rathee D., Thanki M., Agrawal R., Anandjiwala S. Pharmaceutica Analytica Acta. 2010; 1(1): 104. DOI:10.4172/2153-2435.1000104.
  • R. P. Dash, B F. Chauhan, S. Anandjiwala, M. Nivsarkar. Comparative pharmacokinetics profile of Vasa Swaras with vasicine and vasicinone. Chromatographia. 2010; 71(7-8): 609 – 615. DOI: 10.1365/s10337-010-1517-x. (Impact Factor: 1.075)

2009

2009

  • P. Roy, A. F. Shahiwala, Statistical optimization of ranitidine HCl floating pulsatile delivery system for chronotherapy of nocturnal acid breakthrough, European journal of pharmaceutical sciences, 2009, 37(3-4), 363-369.
  • M. Dahiya, S. Saha, A. F. Shahiwala, A review on mouth dissolving films, Current Drug Delivery, 2009, 6(5), 469-76.
  • S. Saha, A. F. Shahiwala, Multifunctional Co-processed excipients for improved tabletting performance, Expert Opinion on Drug Delivery, 2009, 6(2),197-208.
  • B Singh, P Mungara, M Nivsarkar, S Anandjiwala. TLC Densitometric Quantification of Glycyrrhizin, Glycyrrhetinic acid, Apigenin, Kaempferol and Quercetin from Glycyrrhiza glabra using HPTLC. Chromatographia. 2009; 70(11-12): 1665–1672. DOI: 10.1365/s10337-009-1383-6. (Impact Factor: 1.098)

2008

2008

  • P. Roy, A. F. Shahiwala, Statistical optimization of ranitidine HCl floating pulsatile delivery system for chronotherapy of nocturnal acid breakthrough, European journal of pharmaceutical sciences, 2009, 37(3-4), 363-369.
  • M. Dahiya, S. Saha, A. F. Shahiwala, A review on mouth dissolving films, Current Drug Delivery, 2009, 6(5), 469-76.
  • S. Saha, A. F. Shahiwala, Multifunctional Co-processed excipients for improved tabletting performance, Expert Opinion on Drug Delivery, 2009, 6(2),197-208.
  • B Singh, P Mungara, M Nivsarkar, S Anandjiwala. TLC Densitometric Quantification of Glycyrrhizin, Glycyrrhetinic acid, Apigenin, Kaempferol and Quercetin from Glycyrrhiza glabra using HPTLC. Chromatographia. 2009; 70(11-12): 1665–1672. DOI: 10.1365/s10337-009-1383-6. (Impact Factor: 1.098)
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